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Clinical and Scientific Evidence

Simple and effective wound care, whatever the wound type.

HydroTherapy is suitable for the treatment of the majority of acute and chronic wounds.
Select the relevant publication to read the PDF or download to access later.

"They really are a fantastic product and I would recommend these to anyone in my situation. They helped me at a time when I had given up hope of anything working for me."1

Wound healing and hyper hydration:
a counter intuitive model

The optimum moisture levels required to promote healing in a moist environment are not known. This can lead to confusion when considering what level of tissue hydration is adequate and may lead to the development of tissue maceration.

This review article discusses ‘Hyper-Hydration’, a contradictory course of intervention proposing that tissue is hydrated beyond what is considered therapeutically acceptable. The paper then describes the causes and effects of tissue maceration and distinguishes these from the hyper-hydration of tissue.

Download PDF 377,2 KB

The effect of Ringer’s solution within a dressing to elicit pan relief

Clinical studies suggest that dressings containing Ringer’s solution, such as HydroClean® plus, provide relief from wound pain. This report reviews the available evidence and possible mechanisms for the relief of wound pain by these dressings.

Download PDF 89,2 KB

HydroClean® plus: a new perspective to wound cleansing and debridement

A number of clinical studies and case reports have shown that HydroClean® plus effectively cleanses wounds of necrotic tissue, fibrinous slough and bacteria-laden wound exudates.

This product focus review summarises the evidence to date supporting HydroClean® plus and Hydro-Responsive Wound Dressings.

Download PDF 980,3 KB

The importance of hydration in wound healing: reinvigorating the clinical perspective

This review discusses the importance of appropriate levels of hydration in skin, with a particular focus on the need for optimal hydration levels for effective healing.

Download PDF 255,4 KB

Introducing HydroClean® plus for wound-bed preparation: a case series

This study evaluates HydroClean® plus as an alternate method of autolytic debridement within ‘standard’ practice.

The primary objective of the study was to assess HydroClean® plus in aiding wound bed preparation and progression in acute and chronic wounds. Dressing performance – e.g. ease of application/removal and patient/clinician acceptance – when used in routine wound care was also evaluated.

Download PDF 461,2 KB

Wound bed preparation: a novel approach using HydroTherapy

Wounds that fail to heal quickly are often encountered by community nursing staff. An important step in assisting these chronic or stalled wounds progress through healing is debridement to remove devitalised tissue, including slough and eschar, that can prevent the wound from healing. A unique wound treatment called HydroTherapy aims to provide an optimal healing environment.

This paper presents three case studies of slow healing wounds treated with HydroClean® plus which demonstrates effective wound debridement.

Download PDF 309,6 KB

Hydro-Responsive Wound Dressings simplify T.I.M.E wound management framework

The development of wound management protocols and guidelines such as the T.I.M.E. acronym are useful tools to aid wound care practitioners deliver effective wound care. 

This article briefly reviews the principles of T.I.M.E. and describes the evidence for the use of a two dressing, moisture balance oriented, dressing based wound management system for the treatment of wounds that addresses principle requirements of delivering T.I.M.E.

Download PDF 534,4 KB

HydroTherapy Made Easy

Rapid cleansing, early granulation and sustained epithelialisation are key requirements for the e­fficient healing of chronic wounds and wounds with impaired healing. Wound bed preparation offers a systematic framework to aid clinicians in their goal of progressing wounds from impairment to healing.

This Made Easy discusses HydroTherapy (HARTMANN), an innovative approach to the treatment of wounds, where a harmonised, two-step therapy harnesses optimised hydration at all stages of the healing response to promote wound progression and healing.

Download PDF 1 MB

Autolysis: mechanisms of action in the removal of devitalised tissue

Chronic wounds affect millions of people worldwide. In the UK alone, the cost of their treatment is estimated to be between £4.5bn and £5.1bn. The implementation of wound-bed preparation strategies remove the barriers to healing and wound debridement is a key component in preparing the wound bed for wound progression.

This article aims to review one of the several debridement methods available to clinicians: autolytic debridement.

Autolysis (i.e. autolytic debridement) uses the body’s own enzymatic mechanisms to remove devitalised tissue in order to remove the barriers to healing. This review aims to provide clinicians working in wound care with a better understanding of the mechanisms and implications of autolytic debridement.

Download PDF 271,4 KB

HydroClean® plus
Hydro-Responsive Wound Dressing: Clinical and Scientific Monograph

This document focuses on the cleansing and debridement of the wound bed of chronic wounds as part of a phase-adapted wound treatment, promoting the wound bed for new granulation tissue formation and progression of the healing response.

It examines the evidence relating to Hydro-Responsive Wound Dressings (HRWD®) containing superabsorbent polyacrylate particles ‘activated’ with Ringer’s solution.

Download PDF 649,5 KB
Other Clinical Evidence Material

Conference Posters

Image Clinical Evidence Poster

HydroTherapy Poster Booklet

This poster booklet illustrates “Real Life” evidence based medicine in terms of Case Studies which provides information relating to the management of patients with this new treatment programme – HydroTherapy.

As such, this document provides an insight into how the Hydro-Responsive Wound Dressings (HRWD®) HydroClean® plus and HydroTac® can be used to overcome specific clinical challenges relating to debridement and aiding healing progression in a variety of acute and chronic wounds.

Download PDF 2,8 MB


[1] Patient under the care of Tracey Jones Tissue Viability Nurse, Cumbria Partnership NHS Foundation Trust and Kieron McCracken, Tissue Viability Nurse, University Hospitals of Morecambe Bay NHS Foundation Trust.