Mar 04 2016
Epithelial wound closure from neglected topic to therapeutic target
With time, the non-healing wound becomes stuck and cannot reach the next wound-healing phase. To stimulate healing, the wound needs to develop healthy and productive granulation tissue. There are several options for wound bed preparation. Clinicians assume that once granulation tissue is present, epithelialization will follow. However, this step requires great effort and resources to achieve epithelial wound closure. For chronic wounds, there are not many options available, but even fewer non-surgical options. Novel concepts are developed to address this clinical need, with an emphasis on concepts to be used in everyday practice. Early studies on recombinant growth factors were disappointing. A radically new concept has been developed to enhance epithelialization by boosting local growth factor activity. This can be achieved by a novel material composition in a new dressing!